Key result
Propranolol pre-treatment linked to stable heart rates during thyroidectomy despite ~21% drop in cardiac output.
Why the study?
Does propranolol pre-treatment maintain cardiovascular stability during thyroidectomy in thyrotoxic patients?
Observational (n=7)
Does propranolol pre-treatment maintain cardiovascular stability during thyroidectomy in thyrotoxic patients?
Propranolol pre-treatment in thyrotoxic patients maintains stable heart rate and rhythm during thyroidectomy, despite transient expected hemodynamic changes during surgical stimulation.
Propranolol may stabilize heart rate during thyrotoxic thyroidectomy; leaves open confirmation of hemodynamic safety in prospective trials.
The cardiovascular changes during anaesthesia and thyroidectomy have been studied in seven thyrotoxic patients prepared with propranolol. The heart rate and cardiac rhythm remained very stable throughout surgery. A 20% increase in mean arterial pressure occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgery, reaching a maximum of 21% during ligation of the thyroid vessels and returning to pre-operative values by the end of surgery. The fall in cardiac output was accompanied by raised central venous pressure and raised total peripheral resistance.
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Trench et al. (1978) conducted an observational in Thyrotoxicosis (n=7). Propranolol was evaluated on Cardiovascular changes during anaesthesia and thyroidectomy. Thyrotoxic patients pre-treated with propranolol maintained stable heart rates during thyroidectomy, despite a 20% increase in mean arterial pressure and up to a 21% decrease in cardiac output.
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