Key result
IV propranolol blunts significant surges in heart rate and rate-pressure product during laryngoscopy and sternotomy.
Why the study?
The effect of propranolol on controlling heart rate, systolic pressure, and rate-pressure product during cardiac anesthesia was studied to assess its impact during laryngoscopy and sternotomy.
Does prophylactic IV propranolol prevent increases in heart rate and rate-pressure product during laryngoscopy and sternotomy in patients undergoing CABG?
Does prophylactic IV propranolol prevent increases in heart rate and rate-pressure product during laryngoscopy and sternotomy in patients undergoing CABG?
Intravenous propranolol administered prior to laryngoscopy and skin incision effectively blunts the hemodynamic stress response during cardiac anesthesia for CABG.
Propranolol may blunt hemodynamic surges in low-risk CABG patients; hypothesis-generating, needs prospective confirmation before adoption.
The use of propranolol to control heart rate (HR), systolic pressure, and rate-pressure product (RPP) during laryngoscopy and sternotomy was studied in 21 patients, New York Heart Association functional Classes 1 and 2, scheduled for coronary artery bypass graft surgery. All patients were anesthetized in an identical fashion, but the treatment group (N = 13) received propranolol, 0.5 to 1 mg IV, 4 minutes before laryngoscopy and again, in most cases, before skin incision. Patients not given propranolol (N = 8) showed a clinically and statistically significant increase in HR and RPP, whereas HR and RPP remained essentially unchanged from the preanesthetic period in patients given propranolol.
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Safwat et al. (1982) studied Coronary artery bypass graft surgery (n=21). Propranolol vs. No propranolol was evaluated on Heart rate (HR), systolic pressure, and rate-pressure product (RPP). Propranolol prevented the clinically and statistically significant increases in heart rate and rate-pressure product observed in control patients during laryngoscopy and sternotomy.