Key result
In patients with coronary artery disease on chronic propranolol, diazepam-nitrous oxide induction produced no significant hemodynamic changes, but laryngoscopy and intubation significantly increased MAP, HR, and RPP (p<0.01).
Why the study?
Does chronic propranolol therapy alter the hemodynamic responses to diazepam-nitrous oxide anesthesia induction and endotracheal intubation in patients with coronary artery disease?
Population
19 patients with coronary artery disease receiving chronic propranolol therapy
Comparison
Intravenous infusion of diazepam and… vs Previously reported group of similar patients…
Design
Cohort
Follow-up
up to 3 minutes after intubation
Authors
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Intubation provokes significant MAP/HR/RPP surges despite chronic propranolol in CAD; hypothesis-generating for adjunctive blunting strategies in future trials.
Observational (n=19)
Does chronic propranolol therapy alter the hemodynamic responses to diazepam-nitrous oxide anesthesia induction and endotracheal intubation in patients with coronary artery disease?
p-value: p=<0.01
Chronic propranolol therapy does not prevent the transient increases in heart rate and blood pressure associated with laryngoscopy and endotracheal intubation in patients with coronary artery disease.
McCammon et al. (1981) conducted an observational in Coronary artery disease (n=19). Diazepam-nitrous oxide anesthesia induction and endotracheal intubation vs. Previously reported group not receiving propranolol was evaluated on Hemodynamic changes (heart rate, mean arterial pressure, rate-pressure product) (p=<0.01). In patients with coronary artery disease on chronic propranolol, diazepam-nitrous oxide induction produced no significant hemodynamic changes, but laryngoscopy and intubation significantly increased MAP, HR, and RPP (p<0.01).
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