Key result
Pre-incision IV propranolol blunts hemodynamic surges during cardiac anesthesia compared to control.
Why the study?
The effect of propranolol on controlling heart rate, systolic pressure, and rate-pressure product during cardiac anesthesia was studied to assess its impact during laryngoscopy and sternotomy.
Does IV propranolol control heart rate and rate-pressure product during laryngoscopy and sternotomy in patients undergoing CABG?
Does IV propranolol control heart rate and rate-pressure product during laryngoscopy and sternotomy in patients undergoing CABG?
Propranolol administered before laryngoscopy and skin incision effectively prevents significant increases in heart rate and rate-pressure product during CABG surgery.
IV propranolol prevented HR/RPP rises during laryngoscopy/sternotomy in CABG patients; hypothesis-generating and should not yet change practice.
The use of propranolol to control heart rate (HR), systolic pressure, and rate-pressure product (RPP) during laryngoscopy and sternotomy was studied in 21 patients, New York Heart Association functional Classes 1 and 2, scheduled for coronary artery bypass graft surgery. All patients were anesthetized in an identical fashion, but the treatment group (N = 13) received propranolol, 0.5 to 1 mg IV, 4 minutes before laryngoscopy and again, in most cases, before skin incision. Patients not given propranolol (N = 8) showed a clinically and statistically significant increase in HR and RPP, whereas HR and RPP remained essentially unchanged from the preanesthetic period in patients given propranolol.
No takes yet. Share an insight, caveat, or question.
Safwat et al. (1981) studied New York Heart Association functional Classes 1 and 2, scheduled for coronary artery bypass graft surgery (n=21). Propranolol vs. No propranolol was evaluated on Heart rate (HR), systolic pressure, and rate-pressure product (RPP). Propranolol administration before laryngoscopy and skin incision prevented significant increases in heart rate and rate-pressure product during cardiac anesthesia compared to controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: