Why the study?
Does oral propranolol alter hemodynamic parameters in hyperthyroid patients?
Does oral propranolol alter hemodynamic parameters in hyperthyroid patients?
Propranolol effectively reduces the hyperdynamic circulatory state in hyperthyroidism, but caution is advised due to potential baseline elevations in left ventricular end-diastolic pressure.
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May reduce hyperdynamic state in hyperthyroidism; leaves open LVEDP safety concerns in case reports.
Cardiac catheterization and measurements of phases of left ventricular systole were performed in seven hyperthyroid patients before and during the oral administration of propranolol hydrochloride, a betaadrenergic receptor blocking agent. The data suggest that the hyperdynamic circulatory state in hyperthyroidism results from the combination of the direct action of thyroxin on the myocardium and the activation of the beta-adrenergic receptors. Propranolol decreased heart rate, cardiac output, maximum first derivative of left ventricular pressure, mean systolic ejection rate, left ventricular work and left ventricular stroke power induced through the sympathetic nervous system. Caution is urged in its use because of an unexplained left ventricular end-diastolic pressure elevation in more than half of the subjects before treatment.
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Raymond J. Pietras (1972) studied this question.
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