Why the study?
Does beta-blockade with propranolol alter cardiovascular responses differently in hyperthyroid patients compared to euthyroid controls?
Population
10 hyperthyroid patients and age-matched euthyroid controls
Comparison
Beta-blockade with slow-release propranolol vs Baseline and euthyroid controls
Design
Case-control
Follow-up
24 hours
Authors
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Beta-blockade responses appear comparable in hyperthyroidism; hypothesis-generating for direct T3 effects on nocturnal HR independent of adrenergic hypersensitivity.
Does beta-blockade with propranolol alter cardiovascular responses differently in hyperthyroid patients compared to euthyroid controls?
Excess circulating thyroid hormones exert a direct effect on the cardiovascular system that is additive to the sympathetic nervous system, providing no evidence for adrenergic hypersensitivity in hyperthyroidism.
Forfar et al. (1982) studied this question.
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