February 1, 2004Echocardiography
Left Ventricular Long‐Axis Function Is Reduced in Patients with Rheumatic Mitral Stenosis
Key result
Pure mitral stenosis was associated with significantly impaired left ventricular long-axis function, including reduced septal annular motion (12 vs 14.4 mm, P=0.016), despite normal global systolic function.
Why the study?
Is left ventricular long-axis function impaired in patients with pure mitral stenosis despite normal global systolic function?
Population
74 subjects: 52 patients with pure mitral stenosis and normal global systolic function and 22 healthy…
Design
Case-control
Authors
Discussion
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Implication
May prompt long-axis assessment in mitral stenosis echocardiography; leaves open effects on symptoms and prognosis.
Key Points
- To evaluate left ventricular long-axis function using M-mode and tissue Doppler echocardiography in patients with pure mitral stenosis and preserved global systolic function.
- Echocardiographic cross-sectional comparison of 52 patients with pure mitral stenosis and normal global systolic function against 22 healthy control subjects.
- Assessed left ventricular long-axis systolic function via M-mode mitral annular motion and tissue Doppler imaging velocities at both septal and lateral annular sites.
- Patients with mitral stenosis had significantly lower M-mode annular systolic motion than controls at the septal side (12 ± 3 vs 14.4 ± 1.5 mm, P = 0.016) and lateral side (13.2 ± 3 vs 16.8 ± 2 mm, P = 0.001).
- Tissue Doppler systolic velocity was significantly reduced in patients compared to controls at both the septal annulus (7.6 ± 1.1 vs 10.4 ± 3.2 cm/s, P = 0.03) and lateral annulus (7.6 ± 1.1 vs 10.4 ± 3.2 cm/s, P = 0.003).
- Septal annular motion correlated significantly with annular velocity (r = 0.643, P = 0.002), and both motion and velocity correlated with left atrial ejection fraction (r = 0.338, P = 0.005 and r = 0.676, P = 0.001, respectively).
Study Design
Type
Case-Control (n=74)
Structured PICO
Is left ventricular long-axis function impaired in patients with pure mitral stenosis despite normal global systolic function?
P
Population
74 participants, including 52 patients with pure mitral stenosis and normal global systolic function and 22 healthy controls.
C
Comparator
Healthy controls
O
Outcome
Left ventricular long-axis function evaluated by M-mode or tissue Doppler echocardiography (systolic motion and velocity of the mitral annulus)surrogate
Main Result
Absolute Event Rate: 12% vs 14.4%
p-value: p=0.016
Patients with pure mitral stenosis have significantly impaired left ventricular long-axis function despite normal global systolic function.
Cite This Study
Can et al. (2004) conducted a case-control in Pure mitral stenosis (n=74). Pure mitral stenosis vs. Healthy controls was evaluated on M-mode derived systolic motion of the septal side of mitral annulus (p=0.016). Pure mitral stenosis was associated with significantly impaired left ventricular long-axis function, including reduced septal annular motion (12 vs 14.4 mm, P=0.016), despite normal global systolic function.