Key result
In the STZ rat model of diabetes, plantar metatarsal arteries showed reduced nerve-evoked contractions and ~25% lower perivascular nerve fiber density, which were prevented by insulin treatment.
Population
Streptozotocin (STZ) rat model of type 1 diabetes
Comparison
Streptozotocin with or without low or high dose… vs Control rats
Design
Preclinical
Follow-up
12 weeks
Authors
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Diabetes impairs neurovascular transmission in rat arteries; hypothesis-generating for mechanisms of human diabetic neuropathy.
STZ-induced diabetes impairs neurovascular transmission in plantar metatarsal arteries via decreased nerve fiber density and muscle reactivity, whereas in mesenteric arteries, reduced effectiveness of nerve-evoked constrictions is primarily due to increased vascular dimensions.
Johansen et al. (2012) studied Streptozotocin-induced type 1 diabetes. Streptozotocin (STZ) vs. Control was evaluated on Neurovascular function (nerve-evoked contractions, sensitivity to adrenoceptor agonists, perivascular nerve fiber density). In the STZ rat model of diabetes, plantar metatarsal arteries showed reduced nerve-evoked contractions and ~25% lower perivascular nerve fiber density, which were prevented by insulin treatment.
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