Key result
Temporary discontinuation of cardiac resynchronization therapy significantly deviated blood flow momentum from the base-apex orientation, increasing the flow momentum angle by 8.6 degrees (p<0.0001).
Why the study?
Does temporary discontinuation of CRT pacing alter the orientation of left ventricular flow momentum in heart failure patients?
Observational (n=30)
Does temporary discontinuation of CRT pacing alter the orientation of left ventricular flow momentum in heart failure patients?
Mean Difference: 8.6
Absolute Event Rate: 43.3% vs 34.7%
p-value: p=<0.0001
Echocardiographic particle image velocimetry demonstrates that CRT alters left ventricular blood flow momentum orientation, which correlates with long-term reverse remodeling.
Authors
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CRT-induced LV flow momentum re-alignment correlates with volumetric response; leaves open its value for CRT optimization or outcome prediction.
Pedrizzetti et al. (2015) conducted an observational in Heart failure with dilated cardiomyopathy (n=30). Temporary discontinuation of cardiac resynchronization therapy (CRT-OFF) vs. Active cardiac resynchronization therapy (CRT-ON) was evaluated on Flow momentum orientation angle (w) (MD 8.6, p=<0.0001). Temporary discontinuation of cardiac resynchronization therapy significantly deviated blood flow momentum from the base-apex orientation, increasing the flow momentum angle by 8.6 degrees (p<0.0001).
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