What question did this study set out to answer?

Determine how selective and non-selective nitric oxide synthase (NOS) inhibitors modulate neurogenic dural vasodilation and CGRP-mediated meningeal blood vessel dilation.

September 1, 2002British Journal of PharmacologyOpen Access

Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene‐related peptide induced dilation of dural meningeal vessels

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Authors

SASimon AkermanUniversity of Maryland, Baltimore DWDavid J. WilliamsonKing's College - North Carolina HKH KaubeUniversity of Freiburg

Discussion

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Implication

Microscopy study demonstrates that nitric oxide synthase inhibitors reduce neurogenic and CGRP-induced vessel dilation in dural membranes, suggesting distinct neurovascular migraine pathways.

Key Points

Determine how selective and non-selective nitric oxide synthase (NOS) inhibitors modulate neurogenic dural vasodilation and CGRP-mediated meningeal blood vessel dilation.
Applied intravital microscopy to evaluate meningeal vessel diameter changes in real time.
Administered non-specific, neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) inhibitors during neurogenic dural vasodilation and CGRP-evoked vessel dilation.
Non-specific and nNOS inhibitors partially suppressed neurogenic dural vasodilation, whereas iNOS inhibition showed no effect.
Non-specific and eNOS inhibitors partially attenuated CGRP-induced dural vessel dilation, while nNOS inhibition did not alter CGRP-evoked responses.

Cite This Study

Akerman et al. (2002) studied this question.

synapsesocial.com/papers/6a9d5ff03fe8c5aa6429fac8 https://doi.org/10.1038/sj.bjp.0704842

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Implication

Microscopy study demonstrates that nitric oxide synthase inhibitors reduce neurogenic and CGRP-induced vessel dilation in dural membranes, suggesting distinct neurovascular migraine pathways.

Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene‐related peptide induced dilation of dural meningeal vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene‐related peptide induced dilation of dural meningeal vessels

Discussion

Member takes

Implication

Key Points

Cite This Study

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