Sir: Acyl-CoA: cholesterol acyltransferase (ACAT) is a key enzyme for cholesteryl ester accumulation in atherogenesis, lipoprotein formation in livers and cholesterol absorption from intestines.Therefore, ACAT is focused as one of the new inhibition targets for the treatment or prevention of atheroscleosis and hypercholesterolemia.During our course of screening for ACAT inhibitors of microbial origin, purpactins1}, new cyclodepsipep-tides2) and glisoprenins3) were isolated from fungal strains.Our continuous search has led to the
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Ōmura et al. (1993) studied this question.