Key result
Prior statin use was associated with a significantly higher incidence of in-hospital stress-induced hyperglycemia compared to non-statin use among non-diabetic patients with acute myocardial infarction (29.89% vs. 15.10%).
Why the study?
Does statin use increase the risk of stress-induced hyperglycemia and subsequent cardiac events in patients with acute ST-elevation myocardial infarction?
Observational (n=476)
No
Does statin use increase the risk of stress-induced hyperglycemia and subsequent cardiac events in patients with acute ST-elevation myocardial infarction?
Statin use in non-diabetic patients presenting with acute myocardial infarction is associated with an increased risk of stress-induced hyperglycemia, which correlates with higher rates of in-hospital heart failure and mortality.
May prompt closer glucose monitoring in non-diabetic AMI patients on statins; leaves open impact on heart failure or mortality.
BACKGROUND: Only a few information is available on the risk of stress hyperglycemia following acute myocardial infarction after statin use. We investigate the association of stress-induced hyperglycemia following statin use in patients with acute myocardial infarction. METHODS: An observational analysis of 476 consecutive patients who suffered acute myocardial infarction was carried out. All selected patients were divided into diabetes mellitus and non-diabetes based on the presence or absence of diabetes. The cardiac incidence of in-hospital and stress-induced hyperglycemia was recorded. RESULTS: Among patients with stress hyperglycemia in non-diabetes mellitus subgroups, the average fasting plasma glucose values in statin users were higher than in non-statin users (P < 0.05). But in diabetes mellitus subgroups, the average fasting plasma glucose did not have a significant difference between statin users and non-statin users (P > 0.05). In non-diabetes mellitus patients, the incidence of stress hyperglycemia with statin therapy was significantly higher than with non-statin therapy (P = 0.003). But in diabetes mellitus patients group, there is no significant difference in incidence of stress hyperglycemia between patients with statin therapy and patients without statin therapy (P = 0.902).The incidence of heart failure and in-hospital mortality of acute myocardial infarction in patients with stress-induced hyperglycemia was significantly higher than in non-hyperglycemia patients (P < 0.05). CONCLUSION: Statins are related to higher stress hyperglycemia and cardiac incidences after acute myocardial infarction.
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Chen et al. (2016) conducted an observational in Acute ST-elevation myocardial infarction (n=476). Statin use vs. Non-statin use was evaluated on Incidence of stress-induced hyperglycemia in non-diabetic patients (p=0.003). Prior statin use was associated with a significantly higher incidence of in-hospital stress-induced hyperglycemia compared to non-statin use among non-diabetic patients with acute myocardial infarction (29.89% vs. 15.10%).
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