Summary The concentrations of albumin, α, β and γ‐globulins were determined in blood serum and in lymph draining from the hind paws of rabbits before and after L thermal injury induced by immersing one paw in water at 55, 60, 70 or 80° for 60 sec. The protein concentrations in the lymph from the Injured paw increased immediately after injury and gradually returned to levels equal to those in the lymph from the uninjured paw within 7 to 14 days. On the other hand the rate of protein turnover from plasma to lymph determined by measurements of specific activities following the intravenous injection of albumin labelled 131 I returned to normal levels within 1 day after injury. The lymph: serum ratios of the concentrations (CL:C8) were less for α, β‐ and γ‐globulins than for albumin when lymph was collected from the uninjured paw or from the injured paw from I day to β months after injury, suggesting that in the leakage of proteins from plasma a degree of molecular sieving occurred. In lymph collected 0–2 hr. after injury, however, the CL:C8 ratio for γ‐globulin was greater then that for albumin, α‐ or β‐ globulins at all grades of injury. This suggests that immediately after thermal injury a protein which migrates as a γ‐globulin on electrophoresis is released transiently from the injured tissues. The mechanisms concerned in all of these phenomena in relation to the ultrastucture of the small blood vessels have been discussed.
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Roberts et al. (1969) studied this question.