Experimental study demonstrates increased gastric acid secretion after duodenal resection or bypass, indicating an essential inhibitory role of the duodenum.
The output of free HCI by isolated gastric pouches more than doubled following resection of the duodenum and proximal 20 to 30 cm of jejunum. 2. Interposing a segment of small bowel approximately 1.5 meters long between the stomach and duodenum also caused the output of free HCl from isolated gastric pouches to more than double. 3. The marked increase in HCI secretion following both operations was observed in every case and seemed to be independent of the pre-operative level of HCI secretion by the pouches.
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Brackney et al. (1955) studied this question.
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