Key result
Antral tension from hyperperistalsis profoundly stimulates antral endocrine function in canine models.
Why the study?
The mechanisms underlying hypersecretion of gastric juice and peptic ulcer formation following transplantation of the antrum into other organs were not fully understood.
Population
Dogs as experimental models
Comparison
Transplantation of the antrum into transverse colon vs urinary bladder
Design
Preclinical experimental study
Authors
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Antral tension provokes hypersecretion in canine models; leaves open its relevance to human peptic ulcer mechanisms.
Tension within the gastric antrum is a profound stimulus for its endocrine function and subsequent gastric hypersecretion.
Lester R. Dragstedt (1956) studied Gastric hypersecretion and peptic ulcer formation. Transplantation of the stomach antrum into the transverse colon or urinary bladder was evaluated on Gastric secretion and endocrine function of the antrum. Tension within the antrum, especially provoked by hyperperistalsis, was a profound stimulus to the endocrine function of the antrum in experimental dog models.
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