Key result
Resting heart rate showed a J-shaped relationship with all-cause mortality in permanent AF, with rates >65 bpm increasing risk (HR 1.10 per 5-bpm increase; 95% CI 1.05-1.15; P<0.0001).
Why the study?
Is resting heart rate associated with mortality in outpatients with permanent atrial fibrillation?
Observational (n=2,812)
Yes
Is resting heart rate associated with mortality in outpatients with permanent atrial fibrillation?
Hazard Ratio: 1.1 (95% CI 1.05–1.15)
p-value: p=<0.0001
In patients with permanent atrial fibrillation, there is a J-shaped relationship between resting heart rate and mortality, with both lower (≤65 bpm) and higher (>65 bpm) heart rates associated with increased risk.
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Supports individualized rate assessment in permanent AF outpatients; leaves optimal targets open for prospective trials.
Steinberg et al. (2015) conducted an observational in Permanent atrial fibrillation (n=2,812). Resting heart rate vs. Heart rate ≤65 bpm was evaluated on All-cause mortality (HR 1.10, 95% CI 1.05-1.15, p=<0.0001). Resting heart rate showed a J-shaped relationship with all-cause mortality in permanent AF, with rates >65 bpm increasing risk (HR 1.10 per 5-bpm increase; 95% CI 1.05-1.15; P<0.0001).
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