Key result
Vagal nerve discharges were successfully recorded from awake goats, synchronized with respiration, and responded to hemodynamic changes induced by drug administration.
Vagal nerve activity can be successfully recorded in awake goats and responds to hemodynamic changes, suggesting potential utility for predictive control in artificial heart systems.
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Feasibility of awake vagal recording shown in goats; leaves open translation to predictive control in artificial hearts.
To detect useful information for an artificial heart control system, we paid attention to the autonomic nervous system. For stable recording, we used vagal nerve activity in chronic animal experiments using healthy adult goats in an awake condition because this nerve was sufficiently bold and large enough. Vagal nerve discharges were successfully recorded from awake goats. They were synchronized with respiration and responded to the hemodynamic changes induced by drug administration, suggesting that they may provide useful information for an artificial heart control algorithm. For automatic control, some time delay plays a vitally important role. Thus, predictive control for an artificial heart system may be desirable. It may be embodied by the use of autonomic nerve information.
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Yambe et al. (1999) studied this question. Vagal nerve activity recording was evaluated on Vagal nerve discharges synchronization with respiration and response to hemodynamic changes. Vagal nerve discharges were successfully recorded from awake goats, synchronized with respiration, and responded to hemodynamic changes induced by drug administration.
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