What question did this study set out to answer?

To model and analyze the kinetics of D-glucose mutarotation through the formation of a transient open-chain, free-aldehyde intermediate.

The Kinetics of Mutarotation of D-Glucose with Consideration of an Intermediate Free-aldehyde Form

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Kinetic analysis reveals mutarotation pathways in D-glucose solutions, highlighting the mechanistic role of an intermediate free aldehyde.

To model and analyze the kinetics of D-glucose mutarotation through the formation of a transient open-chain, free-aldehyde intermediate.
Formulated mathematical kinetic expressions describing the reversible opening and closing of D-glucose ring structures.
Evaluated anomeric interconversion rates by incorporating a free-aldehyde intermediate state into the reaction mechanism.
Demonstrated that the mutarotation mechanism proceeds via a low-concentration, open-chain aldehyde intermediate between cyclic anomers.
Provided kinetic rate equations that successfully account for the observed interconversion behavior of D-glucose in aqueous media.

Los et al. (1956) studied this question.

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Kinetic analysis reveals mutarotation pathways in D-glucose solutions, highlighting the mechanistic role of an intermediate free aldehyde.