Key result
Endothelial dysfunction and vascular smooth muscle cell hyperreactivity are reviewed as major interacting mechanisms in the pathogenesis of coronary artery spasm.
Why the study?
The underlying pathophysiological mechanisms of coronary artery spasm remain largely unclear, and the relative contributions of endothelial dysfunction and vascular smooth muscle cell hyperreactivity are controversial.
This review highlights the pathophysiological interplay between endothelial dysfunction and vascular smooth muscle cell hyperreactivity in the development of coronary artery spasm.
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May inform mechanistic research on coronary spasm; leaves open targeted therapies pending clinical trials.
Hubert et al. (2020) conducted a review in Coronary artery spasm. Endothelial dysfunction and vascular smooth muscle cell hyperreactivity was evaluated. Endothelial dysfunction and vascular smooth muscle cell hyperreactivity are reviewed as major interacting mechanisms in the pathogenesis of coronary artery spasm.