Key result
Current treatment strategies for different stages of liver cancer, including surgery, transarterial chemoembolization, and microwave ablation, are safe and feasible for patients with SIT-HCC.
Case Report (n=9)
No
Standard liver cancer treatments such as surgery, chemoembolization, and ablation appear safe and feasible in patients with concurrent situs inversus totalis.
Supports feasibility of standard HCC therapies in rare SIT; hypothesis-generating and requires larger studies before practice change.
Hepatocellular carcinoma (HCC) is the most commonly diagnosed carcinoma and one of the leading causes of cancer-related deaths worldwide. Situs inversus totalis (SIT) is a congenital condition where in the internal organs of the abdomen and thorax lie in mirror images of their normal position. Thus far, there are very few reports on cases of SIT coexisting with HCC. Our case series is probably the largest series in world literature. The cohort of this retrospective study included a total of nine patients diagnosed with SIT-HCC and treated in our hospital between January 2013 and May 2018. Clinical characteristics, prognostic factors, and outcomes were summarized. Treatment strategies included surgery, transarterial chemoembolization, and microwave ablation. The diagnosis and treatment of patients with SIT are challenging because of organ reversion. The current treatment strategies for different stages of liver cancer are safe and feasible for patients with SIT-HCC.
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Xu et al. (2016) conducted a case report in Hepatocellular carcinoma with situs inversus totalis (n=9). Liver cancer treatment strategies (surgery, transarterial chemoembolization, microwave ablation) was evaluated on Clinical characteristics, prognostic factors, and outcomes. Current treatment strategies for different stages of liver cancer, including surgery, transarterial chemoembolization, and microwave ablation, are safe and feasible for patients with SIT-HCC.
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