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January 1, 2016RSC Advances

Coumarin-based thiosemicarbazones as potent urease inhibitors: synthesis, solid state self-assembly and molecular docking

Aminah Hameed Muhammad Yaqub Mazhar Hussain Abdul Hameed Muhammad Ashraf Humna Asghar Quart-ul-Ain Quart-ul-Ain Muhammad Moazzam Naseer Khalid Mahmood Muhammad Muddassar Muhammad Nawaz Tahir Zahid Shafiq

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Abstract

A series of coumarin-based thiosemicarbazones and their metal complexes have been synthesized and their in vitro potency against urease was evaluated.

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Hameed et al. (2016) studied this question.

synapsesocial.com/papers/6a9d75ab8abc1d8b83a4c30f https://doi.org/10.1039/c6ra12827k

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent reviewReview · 2011 · 200 citations
2The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal ComplexesOriginal Research · 2004 · 783 citations
3Design, Synthesis, and Characterization of Novel Iron Chelators: Structure−Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor AgentsOriginal Research · 2007 · 222 citations
4Me 3 N-promoted synthesis of 2,3,4,4a-tetrahydroxanthen-1-one: preparation of thiosemicarbazone derivatives, their solid state self-assembly and antimicrobial propertiesOriginal Research · 2015 · 32 citations
5Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological ActivityOriginal Research · 2005 · 995 citations

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