Key result
Phylogenetic and recombination analyses of 134 complete HEV genomes identified three significant recombination events, including a double recombination event between human and swine HEV strains.
This genomic analysis reveals that double recombination events occur in Hepatitis E Virus, including between human and swine strains, highlighting a mechanism for viral evolution and diversity.
Alerts to possible swine-human HEV recombination; extends viral evolution data but leaves open clinical and surveillance implications.
Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant recombination events, including both intra-genotype and one inter-genotype, were identified by recombination detection analysis. Recombination events I and II occurred intra-genotype and inter-genotype, respectively, among three isolates, including the lineage represented by CHN-XJ-SW13 (GU119961, swine isolate), E067-SIJ05C (AB369690, human isolate), and JJT-Kan (AB091394, human isolate), and lead to the recombinant swine isolate swCH31 (DQ450072). Recombination event III occurred between the lineage represented by the NA1 (M73218) and K52-87 (L25595), which resulted in the recombinant Xingjiang-1 (D11092). Our analyses proved that that recombination could occur between human and swine HEV strains, double recombination events existed in HEV, and recombination event could happen within ORF2 region of HEV. These results will provide valuable hints for future research on HEV diversity.
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Wang et al. (2010) studied Hepatitis E Virus (HEV) (n=134). Recombination analysis was evaluated on Identification of recombination events. Phylogenetic and recombination analyses of 134 complete HEV genomes identified three significant recombination events, including a double recombination event between human and swine HEV strains.
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