An enriching experience: Chiral phosphoric acids have been used to catalyze the title transformation for aromatic and aliphatic hemiaminal ethers. The process affords the corresponding products in good to high enantioselectivity (see scheme; Boc = tert-butoxycarbonyl, G = aromatic group). The method enables facile access to highly enantioenriched 1,3-diamine derivatives.
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Terada et al. (2009) studied this question.
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