Key result
Coronary vascular disease was associated with a 42% increase in the proportion of myocardial LDH A subunits compared to controls, whereas chronic systemic hypoxia showed no change.
Why the study?
Does ischemic or hypoxic heart disease alter myocardial LDH isozyme distribution compared to normal coronary arteries?
Population
31 patients undergoing cardiac surgery, including 12 with coronary vascular disease undergoing…
Design
Case-control
Authors
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Suggests coronary disease-specific metabolic remodeling absent in systemic hypoxia; leaves open effects on outcomes or management.
Observational (n=31)
Does ischemic or hypoxic heart disease alter myocardial LDH isozyme distribution compared to normal coronary arteries?
Effect estimate: 42% increase
Ischemic heart muscle exhibits an altered LDH subunit composition shifted toward anaerobic metabolism, a compensatory mechanism not seen in chronic systemic hypoxia.
Hammond et al. (1976) conducted an observational in Ischemic and hypoxic heart disease (n=31). Coronary vascular disease (ischemia) and cyanotic congenital heart defects (hypoxia) vs. Acyanotic congenital heart defects with normal coronary arteries was evaluated on Proportion of LDH A subunits (42% increase). Coronary vascular disease was associated with a 42% increase in the proportion of myocardial LDH A subunits compared to controls, whereas chronic systemic hypoxia showed no change.
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