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February 2, 2024VaccineOpen Access

Longitudinal parental perception of COVID-19 vaccines for children in a multi-site, cohort study

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Authors

PRPatrick RiversUniversity of ArizonaCPCynthia PorterUniversity of ArizonaLLLindsay LeClairAdvanced Bioscience Laboratories (United States)

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Implication

Prospective cohort study observes parental beliefs about safety and efficacy predict COVID-19 vaccination in children, indicating target areas for public health messaging.

Key Points

  • To assess COVID-19 vaccine knowledge, attitudes, and practices (KAP) alongside vaccine uptake over 15 months among parents of pediatric cohorts.
  • Conducted a prospective cohort study (PROTECT study) enrolling 2,837 children aged 6 months to 17 years across multiple sites.
  • Collected sociodemographic data at enrollment and tracked vaccination status and parental KAPs quarterly over 15 months.
  • Evaluated predictors of uptake using univariable and multivariable logistic regression and assessed longitudinal KAP changes using McNemar's test for paired samples.
  • Overall, 61% of enrolled children were vaccinated by October 2022.
  • Positive parental beliefs in safety and effectiveness strongly predicted uptake in children aged 5–11 years (safety aOR 13.1, 95% CI 8.5–20.4; effectiveness aOR 6.4, 95% CI 4.3–9.6) and aged 12+ years (safety aOR 7.0, 95% CI 3.8–13.0; effectiveness aOR 8.9, 95% CI 4.4–18.0).
  • Parents across the cohort reported higher knowledge but more negative beliefs regarding safety, effectiveness, and trust in government at follow-up, while initially hesitant parents shifted toward more positive beliefs.

Cite This Study

Rivers et al. (2024) studied this question.

synapsesocial.com/papers/6a9d7bbc8b36422b9ba4c063https://doi.org/10.1016/j.vaccine.2024.01.016
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