Key result
Polycystic ovarian syndrome was associated with a significantly higher proportion of women having elevated (>30 mg/dL) Lp(a) levels compared to healthy controls.
Why the study?
Do women with polycystic ovarian syndrome have altered serum Lp(a) and lipid profiles compared to healthy women?
Case-Control (n=60)
Do women with polycystic ovarian syndrome have altered serum Lp(a) and lipid profiles compared to healthy women?
Women with PCOS have a higher prevalence of elevated Lp(a) levels (>30 mg/dL) compared to healthy controls, which may contribute to increased cardiovascular risk.
May flag higher CV risk in PCOS; hypothesis-generating and should not yet change practice.
Background: Polycystic ovarian syndrome (PCOS) is associated with dyslipidaemia and may render the affected women "at risk" of developing cardiovascular disease. Lipoprotein(a) [Lp(a)] is an independent risk factor for development of atherosclerosis and along with dyslipidaemia may add to cardiovascular risk. In this background the levels of Lp(a) and lipid profile are assessed in PCOS patients. Material and Methods: The study was carried out on 30 newly diagnosed PCOS subjects aged 18-35 years and 30 age-matched healthy women. Blood samples were collected in a fasting state and serum Lp(a), lipid parameters were estimated. Results: The lipid profile parameters were comparable between patients and control subjects. There was no statistically significant difference in the median [interquartile range (IQR)] Lp(a) levels between patients with PCOS and normal controls. However, the proportion of subjects with elevated (> 30 mg/dL) Lp(a) levels were significantly higher in patients with PCOS compared to control subjects. Conclusion: Elevated Lp(a) levels may contribute for development of atherosclerosis and increased cardiovascular risk in PCOS patients.
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Ravi et al. (2015) conducted a case-control in Polycystic ovarian syndrome (n=60). Polycystic ovarian syndrome vs. Age-matched healthy women was evaluated on Proportion of subjects with elevated (> 30 mg/dL) Lp(a) levels. Polycystic ovarian syndrome was associated with a significantly higher proportion of women having elevated (>30 mg/dL) Lp(a) levels compared to healthy controls.
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