Key result
MiR-21 expression is significantly up-regulated in patients with CHD and negatively regulates the frequency of circulating Treg cells through a TGF-β1/smad-independent signaling pathway.
Why the study?
Does miR-21 regulate Treg cell frequency and gene expression in patients with coronary heart disease?
Population
96 patients, including those with acute myocardial infarction, unstable angina, stable angina, and chest…
Comparison
In vitro transfection of peripheral blood… vs In vitro transfection with a miRNA negative…
Design
Preclinical
Authors
Loading...
MiR-21 may suppress Treg frequency in CHD; leaves open therapeutic targeting in atherosclerosis.
Observational (n=96)
Does miR-21 regulate Treg cell frequency and gene expression in patients with coronary heart disease?
MiR-21 negatively regulates circulating Treg cells through a TGF-β1/smad-independent pathway in patients with coronary heart disease, highlighting a potential mechanistic target in atherosclerosis.
Li et al. (2015) conducted an observational in Coronary heart disease (n=96). miR-21 expression vs. Patients with chest pain syndrome was evaluated on Frequency of circulating Treg cells and expression of foxp3, TGF-β1, and smad7. MiR-21 expression is significantly up-regulated in patients with CHD and negatively regulates the frequency of circulating Treg cells through a TGF-β1/smad-independent signaling pathway.