May 1, 1997Tissue Antigens
MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane‐encoded triplet repeat polymorphism
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Discussion
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Implication
Case-control study reveals altered MICA triplet repeat frequencies in Caucasian ankylosing spondylitis, suggesting additional susceptibility factors within the HLA-B27 haplotype.
Key Points
- To assess whether a transmembrane triplet repeat microsatellite polymorphism in the MICA gene contributes to the pathogenesis of ankylosing spondylitis.
- Conducted a genetic linkage and association analysis of a triplet repeat microsatellite in the transmembrane region of MICA.
- Compared Caucasian patients with ankylosing spondylitis against ethnically matched healthy controls, stratifying cohorts by HLA-B27 status.
- The (GCT/AGC)4 microsatellite allele occurred at a significantly higher frequency in ankylosing spondylitis patients compared to matched controls (Pc < 0.0000001).
- Among HLA-B27-positive individuals, the frequency of the (GCT/AGC)4 allele was significantly lower in patients than in healthy controls (Pc = 0.0145).
Cite This Study
Goto et al. (1997) studied this question.