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June 1, 2016Therapeutics and Clinical Risk ManagementOpen Access

Effects of no-reflow phenomenon on ventricular systolic synchrony in patients with acute anterior myocardial infarction after percutaneous coronary intervention

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Key result

The no-reflow phenomenon after PCI for acute anterior myocardial infarction was associated with a higher 6-month incidence of major adverse cardiac events compared to reflow (53.85% vs 8.11%, P<0.001).

Why the study?

Does the no-reflow phenomenon worsen ventricular systolic synchrony and clinical outcomes in patients with acute anterior myocardial infarction after PCI?

Population

100 patients with acute anterior myocardial infarction after percutaneous coronary intervention (PCI)

Comparison

No-reflow phenomenon vs Reflow phenomenon

Design

Cohort

Follow-up

6 months

Authors

LLLiang LiLWLe WangGLGang Liu

Discussion

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Member takes

Overview

No-reflow after anterior MI PCI was associated with higher 6-month MACE; leaves open causal role and need for prospective validation.

Study Design

Type

Cohort (n=100)

Structured PICO

Does the no-reflow phenomenon worsen ventricular systolic synchrony and clinical outcomes in patients with acute anterior myocardial infarction after PCI?

P
Population
100 patients with acute anterior myocardial infarction after percutaneous coronary intervention, followed for 6 months to assess the effects of the no-reflow phenomenon.
E
Exposure
No-reflow phenomenon (assessed by myocardial blush grades)
C
Comparator
Reflow phenomenon
O
Outcome
Left ventricular function and left ventricular systolic synchrony parameters (measured by equilibrium radionuclide angiography) at 6 monthssurrogate

Main Result

Absolute Event Rate: 53.85% vs 8.11%

p-value: p=<0.001

The no-reflow phenomenon after PCI for acute anterior myocardial infarction is associated with reduced left ventricular systolic synchrony and a significantly higher rate of major adverse cardiac events at 6 months.

Cite This Study

Li et al. (2016) conducted a cohort in Acute anterior myocardial infarction (n=100). No-reflow phenomenon vs. Reflow was evaluated on Major adverse cardiac events (p=<0.001). The no-reflow phenomenon after PCI for acute anterior myocardial infarction was associated with a higher 6-month incidence of major adverse cardiac events compared to reflow (53.85% vs 8.11%, P<0.001).

synapsesocial.com/papers/6a9d7ea19675ea02512a0c2ehttps://doi.org/10.2147/tcrm.s107808
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1"No-Reflow" Phenomenon Following Percutaneous Coronary Intervention: An Uncommon Complication2000 · 12 citations
  2. 2Left ventricular remodelling after myocardial infarction: importance of residual myocardial viability and ischaemia2003 · 17 citations
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  4. 4Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning2006 · 19 citations
  5. 5Myocardial contrast echocardiography is superior to other known modalities for assessing myocardial reperfusion after acute myocardial infarction2003 · 77 citations