Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats

Fatma A. Moharram; Fadila M Hamed; Elsayed K. El-Sayed; Shimaa K. Mohamed; Asmaa A. Ahmed; Sabah H. El-Gayed; Mohammed Abdelrazek; Kuei-Hung Lai; Yara E. Mansour; Mohamed S. Mady; Heba E. Elsayed

doi:10.1016/j.heliyon.2024.e39207

October 1, 2024HeliyonOpen Access

Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats

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Key Points

To evaluate the chemical profile and neuroprotective properties of petroleum ether extracts from three palm tree species against glutamate-mediated excitotoxicity in rats.
Assessed petroleum ether extracts from three palm species against monosodium glutamate (MSG)-induced excitotoxicity in a rat model.
Measured apoptotic markers, DNA damage markers, and NR2B subunit expression levels.
Conducted in silico molecular docking against SOD-1 and NR2B-NMDAR targets to identify binding interactions.
Palm tree extracts reduced cellular apoptosis, attenuated DNA damage, and modulated NR2B subunit expression in MSG-treated rats.
Molecular docking identified that lipophilic bioactive constituents from the extracts bound effectively to both SOD-1 and NR2B-NMDAR receptors.

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Implication

Preclinical animal and computational evaluation demonstrates neuroprotection by palm tree extracts against glutamate excitotoxicity in rats, suggesting therapeutic potential for brain injury.

Abstract

level, and NR2B subunit expression and attenuated apoptosis and DNA damage. The docking results show that most active natural compounds bind to SOD-1 and NR2B-NMDARs, verifying the credibility of the biological findings. To sum up, the PEE of the three investigated palm tree species possessed a unique blend of lipophilic bioactive constituents that exert promising neuroprotective potential against MSG-induced excitoneurotoxicity. However, further preclinical investigation and pharmaceutical formulation are needed.

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Moharram et al. (2024) studied this question.

synapsesocial.com/papers/6a9d804c3ad19a20338b1927 https://doi.org/10.1016/j.heliyon.2024.e39207

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Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats

Key Points

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Implication

Abstract

Discussion

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Chemical characterization, neuroprotective effect, and in-silico evaluation of the petroleum ether extract of three palm tree species against glutamate-induced excitotoxicity in rats

Key Points

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Implication

Abstract

Discussion

Cite This Study

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