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September 19, 2025Central Nervous System Agents in Medicinal Chemistry

Neuroprotective and Antioxidant Effects of Pseudoelephantopus spicatus

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Authors

SWS. WarsiAPAnwar ParvezANAbdullah Al Noman

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Overview

This study assesses antioxidant effects and anxiolytic properties in mice, suggesting possible neuroprotective benefits of pseudoelephantopus spicatus.

Key Points

  • MEPS displays significant antioxidant activity with 13.264 mg GAE/g for phenolics and 43.692 mg QE/g for flavonoids.
  • Behavioral tests demonstrate dose-dependent anxiolytic and antidepressant effects, especially at 200 mg/kg (p < 0.001).
  • Molecular docking reveals strong binding to the GABA receptor, particularly for 9,12-octadecadienoic acid (-6.6 kcal/mol).
  • These findings validate the traditional use of pseudoelephantopus spicatus and indicate its potential for treating neurological disorders.

Cite This Study

Warsi et al. (2025) studied this question.

synapsesocial.com/papers/68d46cd731b076d99fa6955ehttps://doi.org/10.2174/0118715249382386250831055558
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