Key result
Postprandial lipemia is modulated by dietary lipids, carbohydrates, and fibers, and exaggerated postprandial lipid responses are associated with atheroma deposition and coronary events.
This review highlights the importance of the postprandial state in lipid metabolism and its potential direct involvement in atherogenesis.
May inform dietary strategies targeting postprandial lipemia; leaves open whether such modulation reduces coronary events.
― The present review deals with the nutritional and metabolic aspects of postprandial lipemia. The postmeal state is characterized by the accumulation of triglyceride-rich lipoproteins (TRL) in the plasma. This is due to the competition for clearance between hepatically-derived very low den- sity lipoproteins (VLDL) and intestinally-derived chylomicrons. At the same time, an important remod- eling of the low density lipoprotein (LDL) and high density lipoprotein (HDL) particles takes place. The amplitude and/or time-course of the occurrence of the postprandial triglyceride response is influenced by the quantity of dietary lipids (triglycerides, cholesterol), the fatty acid composition of dietary triglycerides and the amount and nature of dietary carbohydrates and fibers. The preexisting metabolic sta- tus of the subjects markedly influences the postprandial response; ie, hyperlipidemic, diabetic and obese subjects can exhibit an exaggerated increase in triglycerides and lipoprotein remodeling. The hypothesis that postprandial lipid modifications are associated with atheroma deposition and coro- nary events has been supported by several experimental observations. Despite the significant amount of knowledge already obtained in this field, further research is needed to better elucidate the existing relationships between dietary intake, postprandial response and pathological events. lipid metabolism / lipoproteins / postprandial state / nutrition / pathology Rsum ― Lipmie postprandiale : aspects nutritionnels et mtaboliques. Cette revue traite des aspects nutritionnels et mtaboliques de la priode postprandiale. L'tat postprandial est carac- tris par l'accumulation des lipoprotines riches en triglycrides dans le plasma, cause de la com- ptition existant pour la d airance des lipoprotines d'origine hpatique (VLDL) et intestinale (chylo- microns). Paralllement, on assiste un important remodelage des lipoprotines LDL et HDL. L amplitude et la cintique de l'hypertriglycridmie postprandiale sont modules par la quantit de lipides alimentaires ingrs (triglycrides, cholestrol), la composition en acides gras des lipides, la nature et
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Denis Lairon (1996) conducted a review in Postprandial lipemia. Dietary factors (lipids, carbohydrates, fibers) was evaluated. Postprandial lipemia is modulated by dietary lipids, carbohydrates, and fibers, and exaggerated postprandial lipid responses are associated with atheroma deposition and coronary events.
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