Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 10, 1998Human Gene Therapy

High Doses of a Helper-Dependent Adenoviral Vector Yield Supraphysiological Levels of α 1 -Antitrypsin with Negligible Toxicity

View Full Paper
Ask AI
Bookmark
Share

Authors

NMNúria MorralIndiana University – Purdue University IndianapolisRPRobin J. ParksUniversity of OttawaHZHeshan ZhouBaylor College of Medicine

Discussion

Loading...

Member takes

Implication

Key Points

Key points are not available for this paper at this time.

Cite This Study

Morral et al. (1998) studied this question.

synapsesocial.com/papers/6a9d80e030bdd6b10046e64ahttps://doi.org/10.1089/hum.1998.9.18-2709
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.1994 · 626 citations
  2. 2Persistence in muscle of an adenoviral vector that lacks all viral genes1997 · 293 citations
  3. 3Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.1994 · 1,584 citations
  4. 4A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E41996 · 174 citations
  5. 5Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses1995 · 1,036 citations