Key result
Ingestion of 300 mg acetylsalicylic acid significantly decreased collagen-induced release of PDGF (from 21.5 to 1.8 pg/(mL x 10^6 platelets)) and beta-TG in platelet-rich plasma.
Why the study?
Does acetylsalicylic acid reduce the release of PDGF, beta-TG, and TxB2 in healthy volunteers?
Does acetylsalicylic acid reduce the release of PDGF, beta-TG, and TxB2 in healthy volunteers?
Absolute Event Rate: 1.8% vs 21.5%
Low-dose acetylsalicylic acid inhibits collagen-induced release of PDGF and beta-TG, suggesting a potential mechanism for its effects on atherosclerosis and restenosis.
Should not yet change practice; hypothesis-generating for aspirin's effects on atherosclerosis and restenosis.
Platelet-derived growth factor (PDGF) and beta-thromboglobulin (beta-TG) are released from alpha granules during platelet activation. PDGF may play a role in the development of atherosclerosis and the late restenosis after percutaneous transluminal coronary angioplasty (PTCA). The effect of acetylsalicylic acid (ASA) on PDGF release was studied in healthy volunteers before and twelve hours after ingestion of 300 mg ASA. PDGF, beta-TG, and thromboxane B2(TxB2) were measured by radioimmunoassay (RIA) in serum and in platelet rich plasma (PRP) after submaximal stimulation with collagen. TxB2 decreased significantly from 0.9 +/- 0.3 ng/(mL x 10(6) platelets) to 0.006 +/- 0.005 ng/(mL x 10(6) platelets) (mean +/- SD) in serum after ASA ingestion while PDGF and beta-TG remained unchanged. Measurements in PRP after stimulation with collagen showed a significant decrease in PDGF (from 21.5 +/- 1.4 pg/(mL x 10(6) platelets) to 1.8 +/- 4.1 (pg/mL x 10(6) platelets), in beta-TG (from 21.0 +/- 13.3 ng/(mL x 10(6) platelets) to 2.2 +/- 1.4 ng/(mL x 10(6) platelets)) and in TxB2 (from 143.6 +/- 80.7 pg/(mL x 10(6) platelets) to 0.5 +/- 0.6 pg/(mL x 10(6) platelets)) after treatment with ASA. In conclusion low-dose ASA inhibits collagen-induced release of both beta-TG and PDGF in PRP and TxB2-synthesis in PRP and serum.
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Vissinger et al. (1993) studied Healthy volunteers. Acetylsalicylic acid (ASA) vs. Before ingestion (baseline) was evaluated on PDGF release in platelet rich plasma after stimulation with collagen (pg/(mL x 10(6) platelets)). Ingestion of 300 mg acetylsalicylic acid significantly decreased collagen-induced release of PDGF (from 21.5 to 1.8 pg/(mL x 10^6 platelets)) and beta-TG in platelet-rich plasma.
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