Liver function tests were performed on 20 human volunteers before, during, and after the long‐term administration of morphine. No significant differences in the serum glutamic‐oxaloacetic tramaminase, serum glutamic‐pyruvic tramminase, thymol turbidity, or cephalin flocculation were found. It is concluded that the high incidence of abnormal liver function tests observed in morphine and heroin addicts is not due to a direct hepatotoxic effect of the drug.
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Gorodetzky et al. (1968) studied this question.