Simple Three-Step Synthesis of (R)- and (S)-4-Amino-3-hydroxybutanoic Acid (GABOB) by Stereoselective Aldol Addition

All articles of this category A simple synthesis of both ( R )- and ( S )-GABOB (5) is reported. In the key step, doubly deprotonated ( R )- or ( S )-2-Hydroxy-1,2,2-triphenylethyl acetate (HYTRA) (1) is added to Cbz-protected glycinal ( 2) .