Buchwald–Hartwig Amination of (Hetero)aryl Chlorides by Employing Mor‐DalPhos under Aqueous and Solvent‐Free Conditions

We report on the application of the [Pd(cinnamyl)Cl]2/Mor‐DalPhos catalyst system in the Buchwald–Hartwig amination of (hetero)aryl chlorides with primary or secondary amines conducted either under aqueous conditions without the use of co‐solvents and/or surfactants or under solvent‐free conditions (52 examples). We have established that reactions of this type can be conducted without the rigorous exclusion of air, and in the case of the solvent‐free reactions, we have demonstrated that appropriately selected liquid and solid reagents can be employed successfully.