Key result
Linear isochronal behavior exists in systolic pressure-thickness relations, especially near end systole, and is maintained during modest inotropic alterations.
Linear isochronal behavior exists in systolic pressure-thickness relations, particularly near end systole, and is maintained during modest inotropic alterations in a canine model.
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May inform ventricular mechanics models in research; leaves open clinical translation beyond canine data.
Funai et al. (1988) studied this question. Abrupt preload alterations during dobutamine and propranolol vs. Control was evaluated on Shape and time-varying behavior of pressure-thickness isochrones. Linear isochronal behavior exists in systolic pressure-thickness relations, especially near end systole, and is maintained during modest inotropic alterations.
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