What is the clinical evidence from this study?

Study design: Case Report. Population: Primary intracerebral hemorrhage (n=1). Intervention: Sudden emotional upset. Primary outcome: Fatal primary thalamic/brain stem hemorrhage and autopsy findings.

What question did this study set out to answer?

To evaluate the vascular and histopathological mechanisms that link acute emotional distress to primary intracerebral hemorrhage.

June 1, 2000StrokeOpen Access

Stress-Related Primary Intracerebral Hemorrhage

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Key result

Sudden emotional upset was associated with a fatal primary thalamic/brain stem hemorrhage, with autopsy revealing small-vessel fibrinoid necrosis and rupture.

Population

A single case of fatal primary thalamic/brain stem hemorrhage occurring in the context of sudden emotional…

Design

Case_report

Authors

GLG. Alistair LammieUniversity Hospital of Wales RLRichard I. LindleyUniversity of Technology Sydney SKSarah KeirWestern General Hospital

Discussion

Member takes

Implication

Acute emotional stress may precipitate ICH; case report is hypothesis-generating and leaves causal inference open.

Key Points

To evaluate the vascular and histopathological mechanisms that link acute emotional distress to primary intracerebral hemorrhage.
Postmortem neuropathological examination was conducted following a fatal thalamic and brainstem hemorrhage that occurred immediately after sudden emotional upset.
Autopsy demonstrated perforating artery fibrinoid necrosis adjacent to and distant from the primary hematoma site.
Histopathology revealed pre-existing old lacunar infarcts alongside healed destructive small-vessel lesions throughout the brain.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A single case of fatal primary thalamic/brain stem hemorrhage occurring in the context of sudden emotional upset.

Exposure

Sudden emotional upset (stress)

Outcome

Fatal primary thalamic/brain stem hemorrhage and autopsy findings

Sudden emotional upset may cause a sudden rise in blood pressure or cerebral blood flow, mediating small-vessel fibrinoid necrosis and rupture leading to intracerebral hemorrhage.

Cite This Study

Lammie et al. (2000) conducted a case report in Primary intracerebral hemorrhage (n=1). Sudden emotional upset was evaluated on Fatal primary thalamic/brain stem hemorrhage and autopsy findings. Sudden emotional upset was associated with a fatal primary thalamic/brain stem hemorrhage, with autopsy revealing small-vessel fibrinoid necrosis and rupture.

synapsesocial.com/papers/6a9d98009675ea02512a16cc https://doi.org/10.1161/01.str.31.6.1426

Topics

Hypertension management

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Stress-Related Primary Intracerebral Hemorrhage

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Stress-Related Primary Intracerebral Hemorrhage

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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Topics

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