Key result
Maternal-to-infant transmission of Trypanosoma cruzi occurs in 1% to 5% of cases, and untreated congenital infection leads to potentially fatal cardiac manifestations in 20% to 40% of infants.
Why the study?
Chagas disease is underappreciated as a health concern in the United States, where approximately 40 000 women of childbearing age have chronic infection and most are unaware it is transmissible to their offspring.
Population
Women of childbearing age with chronic Chagas disease and neonates with congenital Trypanosoma cruzi…
Design
Review
Authors
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May support screening at-risk pregnant women for Chagas; leaves open prospective trials on transmission prevention.
Screening at-risk pregnant women for Chagas disease is crucial to identify maternal infection and allow early, curative treatment of congenital transmission to prevent future fatal cardiac manifestations.
Edwards et al. (2019) conducted a review in Congenital Chagas Disease. Maternal-to-infant transmission of Trypanosoma cruzi occurs in 1% to 5% of cases, and untreated congenital infection leads to potentially fatal cardiac manifestations in 20% to 40% of infants.
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