Key result
Two endothelin receptor subtypes mediate contraction of the rabbit saphenous vein: a high-affinity ETB receptor (PKC-independent) and an ETA receptor (PKC-dependent).
In the rabbit saphenous vein, ET-1 induced contraction is predominantly mediated by a high-affinity ETB receptor independently of PKC, with a minor contribution from an ETA receptor via a PKC-dependent mechanism.
No takes yet. Share an insight, caveat, or question.
Distinguishes PKC pathways in rabbit venous ET signaling; hypothesis-generating for human receptor-targeted therapies.
Gray et al. (1994) studied this question. Endothelin (ET-1, ET-3, sarafotoxin S6c) was evaluated on Contraction of rabbit saphenous vein and receptor binding characteristics. Two endothelin receptor subtypes mediate contraction of the rabbit saphenous vein: a high-affinity ETB receptor (PKC-independent) and an ETA receptor (PKC-dependent).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: