Key result
Autoantibodies, including anti-myosin heavy chain, anti-M2 muscarinic receptor, and anti-heat shock protein, are present in atrial fibrillation, though their exact pathogenic role remains unclear.
Autoimmunity may play an important role in the pathogenesis of atrial fibrillation, with at least three types of autoantibodies identified, though their exact roles require further investigation.
Supports exploring autoimmunity in AF; leaves open whether autoantibodies are causal or therapeutic targets.
Atrial fibrillation (AF) is one of the most common arrhythmias in patients with congestive heart failure, although the underlying mechanism has still to be determined. There is increasing evidence to suggest that autoimmunity may play an important role in the pathogenesis of AF. To date, at least three types of autoantibody have been found in AF: the anti-myosin heavy chain autoantibody, the anti-M2 muscarinic receptor autoantibody and the anti-heat shock protein autoantibody. The question is: are these autoantibodies actors, biomakers or merely bystanders? How much knowledge do we have?
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Baba et al. (2008) conducted a review in Atrial fibrillation. Autoantibodies was evaluated. Autoantibodies, including anti-myosin heavy chain, anti-M2 muscarinic receptor, and anti-heat shock protein, are present in atrial fibrillation, though their exact pathogenic role remains unclear.
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