Key result
Patients with lone paroxysmal atrial fibrillation had a significantly higher prevalence of increased IgG autoantibodies to M2-cholinoceptors compared to patients with AF and arterial hypertension.
Why the study?
The study was conducted to assess autoantibodies to M2-cholinoreceptors as a potential development factor of arrhythmia in patients with paroxysmal lone AF and in patients with AF and arterial hypertension.
Do levels of autoantibodies to M2-cholinoceptors differ between patients with paroxysmal lone atrial fibrillation and those with AF and arterial hypertension?
Observational (n=184)
No
Do levels of autoantibodies to M2-cholinoceptors differ between patients with paroxysmal lone atrial fibrillation and those with AF and arterial hypertension?
Patients with lone paroxysmal atrial fibrillation have a higher prevalence of IgG autoantibodies to M2-cholinoceptors compared to those with AF and hypertension, suggesting an autoimmune mechanism in arrhythmogenesis.
May support autoimmune role in lone paroxysmal AF; hypothesis-generating and requires prospective validation before clinical use.
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Миронова et al. (2019) conducted an observational in Paroxysmal atrial fibrillation (n=184). Lone atrial fibrillation vs. Atrial fibrillation with arterial hypertension was evaluated on Prevalence of increased IgG autoantibodies to M2-cholinoceptors (p=<0.05). Patients with lone paroxysmal atrial fibrillation had a significantly higher prevalence of increased IgG autoantibodies to M2-cholinoceptors compared to patients with AF and arterial hypertension.
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