Why the study?
Are antipeptide autoantibodies against the M2 muscarinic receptor associated with bradycardia and autonomic dysfunction in Chagas disease?
Population
Trypanosoma cruzi infected patients with bradycardia and other autonomic nervous system abnormalities, and…
Comparison
Presence of antipeptide autoantibodies against… vs Normal subjects; absence of antibodies or…
Design
Cross-sectional
Authors
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Supports autoimmune contribution to chagasic bradycardia; leaves open causality and need for prospective validation.
Are antipeptide autoantibodies against the M2 muscarinic receptor associated with bradycardia and autonomic dysfunction in Chagas disease?
Circulating antipeptide autoantibodies against the M2 muscarinic receptor are strongly associated with bradycardia and autonomic dysfunction in Chagas disease, suggesting an autoimmune mechanism in chagasic cardioneuromyopathy.
Goin et al. (1999) studied this question.
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