Population
Normal human and murine striated muscles, purified cardiac membranes, and normal murine heart models
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether similar receptor modulation contributes to human chagasic cardiomyopathy.
The anti-Trypanosoma cruzi monoclonal antibody CAK20.12 directly modulates cardiac physiology by activating beta-adrenergic and muscarinic receptors, providing mechanistic insight into the pathogenesis of chronic chagasic myocardiopathy.
Cremaschi et al. (1995) studied this question.
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