Invasive Squamous Cell Carcinoma of the Uterine Cervix I. Definition of parameters in a histopathologic malignancy grading system

A histologic malignancy grading system for invasive squamous cell carcinoma of the uterine cervix is presented. The method is based upon evaluation of the tumour cell population in terms cell differentiation, structure, nuclear polymorphism and the frequency of mitotic figures in terms of a 1 to 3 point scale. The tumour-host relationship was also estimated in terms of a 1 to 3 point scale, by the mode of invasion, stage of invasion, vascular invasion and degree of lymphoplasmocytic infiltration. These parameters permitted a grading with 8 to 24 points totally.