Key result
In rats with experimental autoimmune myocarditis induced by synthetic peptides, heart- and pericardial space-infiltrating T cells were oligoclonal with a predominance of Vbeta4 and similar CDR3 motifs.
In a rat model of experimental autoimmune myocarditis, lesion-infiltrating T cells show oligoclonal expansion of Vbeta4+ cells with similar CDR3 motifs, indicating they may recognize the same epitope.
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Indicates epitope-specific T-cell autoimmunity in rat myocarditis; hypothesis-generating for Vbeta4-targeted therapies in patients.
Hanawa et al. (1998) studied Experimental autoimmune myocarditis (n=12). Immunization with synthetic peptides of cardiac myosin was evaluated on Macroscopic signs of myocarditis and T-cell clonotypes. In rats with experimental autoimmune myocarditis induced by synthetic peptides, heart- and pericardial space-infiltrating T cells were oligoclonal with a predominance of Vbeta4 and similar CDR3 motifs.
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