Key result
The addition of dexamethasone to ropivacaine in transversus abdominis plane block significantly prolonged the time to first rescue analgesia from 11.62 hours to 19.04 hours in patients undergoing lower-segment cesarean section.
Why the study?
To measure the effect of adding dexamethasone to ropivacaine on the duration and quality of post-operative analgesia in patients undergoing lower-segment caesarean section receiving ultrasound-guided TAP blocks.
Does adding dexamethasone to ropivacaine improve the duration and quality of post-operative analgesia in patients undergoing lower-segment cesarean section with ultrasound-guided TAP block?
RCT (n=60)
Double-blind
chit-box approach
No
Does adding dexamethasone to ropivacaine improve the duration and quality of post-operative analgesia in patients undergoing lower-segment cesarean section with ultrasound-guided TAP block?
Absolute Event Rate: 19.04% vs 11.62%
p-value: p=<0.001
The addition of dexamethasone to ropivacaine in ultrasound-guided TAP blocks significantly prolongs post-operative analgesia and reduces opioid requirements in patients undergoing lower-segment cesarean section.
Supports opioid-sparing analgesia after cesarean section; extends RCT evidence for dexamethasone as TAP block adjunct.
Aim: The aim of this study was to measure the effect of adding dexamethasone to ropivacaine on the duration and quality of post-operative analgesia in patients undergoing lower-segment caesarean section (LSCS) who are receiving ultrasound-guided transverse abdominal plane (TAP) blocks. Methods: An interventional, prospective, randomized, and double-blind trial was conducted at a hospital. Before beginning the investigation, the Institutional Ethics Committee permission was acquired. The patient characteristics were analyzed using the Students t-test for continuous variables and the Chi-square test for categorical variables. A total of 60 patients were randomly split into two groups of 30 each. Results: Time to first rescue analgesia was significantly shorter in Group R (11.62±3.80 h) than the Group D (19.04±4.20 h) (p<0.001). The total tramadol requirement in post-operative period was significantly higher in Group R (86.67±30.55 mg) than the Group D (35.56±39.54 mg) (p<0.001). Conclusion: The use of dexamethasone along with 0.1% ropivacaine prolongs the analgesic duration of TAP block in patients undergoing LSCS.
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DEGANWA et al. (2023) conducted an RCT in Lower-segment cesarean section (LSCS) (n=60). Dexamethasone as an adjuvant to ropivacaine vs. 2 mL normal saline with 20 mL 0.1% ropivacaine was evaluated on Time to first rescue analgesia (hours) (p=<0.001). The addition of dexamethasone to ropivacaine in transversus abdominis plane block significantly prolonged the time to first rescue analgesia from 11.62 hours to 19.04 hours in patients undergoing lower-segment cesarean section.
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