Key result
The Starling filtration-absorption theory applies only transiently until dynamic extravascular forces, such as tissue fluid pressure and lymph flow, readjust to oppose transcapillary fluid movement.
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Design
Review
Challenges classic Starling assumptions in fluid management; leaves open validation of dynamic extravascular models for edema research.
It is commonly thought that fluid is filtered in the arterial and is absorbed in the venous end of the capillary, cuased by the considerable hydrostatic pressure difference between the arterial and the venous end, while the transcapillary colloid osmotic pressure difference remains nearly constant. We now know that extravascular forces, i.e., tissue fluid pressure, tissue colloid osmotic pressure, and lymph flow, are dynamic factors that change to oppose transcapillary fluid movement. Therefore, the filtration-absorption theory will apply only transiently until the tissue forces readjust.
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Taylor et al. (1987) reported a review. The Starling filtration-absorption theory applies only transiently until dynamic extravascular forces, such as tissue fluid pressure and lymph flow, readjust to oppose transcapillary fluid movement.
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