Key result
Arteriolar vasomotion protects capillary-tissue fluid balance during elevated capillary flow in theoretical models.
Theoretical modeling suggests arteriolar vasomotion is a primary mechanism protecting capillary-tissue fluid balance during elevated capillary flow.
Theoretical models of vasomotion merit inclusion in capillary fluid simulations; leaves open clinical translation pending in vivo validation.
Flow autoregulation in the arteriolar network serves to maintain the capillary-tissue fluid balance by regulation of capillary pressure. In the present study, we have examined theoretically the effects of arteriolar vasomotion and venous pressure elevation on the capillary fluid exchange, the interstitial fluid pressure, and the interstitial osmotic pressure during capillary pressure regulation. We used Starling's hypothesis and extended it to include a consideration of a parallel hetero-porous pathway and to determine the effects of plasma protein filtration on interstitial fluid pressure and osmotic pressure. We have found that arteriolar vasomotion plays a primary role in protecting the capillary-tissue fluid balance during the elevation of capillary flow and that it is a secondary mechanism for the regulation of capillary arterial pressure.
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Noriko Iida (1990) studied Capillary-tissue fluid balance. Arteriolar vasomotion and venous pressure elevation was evaluated on Capillary fluid exchange, interstitial fluid pressure, and interstitial osmotic pressure. Theoretical modeling demonstrated that arteriolar vasomotion plays a primary role in protecting capillary-tissue fluid balance during the elevation of capillary flow.
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